TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Binding affinity of Norditerpenoid Alkaloids at rat neuronal alpha7-type nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential prei...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -80 mV holding potential incu...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential prei...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Binding affinity of Norditerpenoid Alkaloids at rat neuronal alpha7-type nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Binding affinity of Norditerpenoid Alkaloids at rat neuronal alpha7-type nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 9.5nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: >10nMAssay Description:The compound was tested for its binding affinity against nicotinic receptor in synaptic membrane fractions from rat cerebral cortices.More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat hipocampusMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat amygdalaMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Compound was tested for its binding affinity against nicotinic receptor in synaptic membrane fractions from rat cerebral cortices.More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 12.2nM ΔG°: -11.2kcal/mole IC50: 14.1nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potentia...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Compound was tested for its binding affinity against nicotinic receptor in synaptic membrane fractions from rat cerebral cortices.More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potentia...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cellsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cellsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cellsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 20.4nM ΔG°: -10.9kcal/mole IC50: 23.6nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 20.6nM ΔG°: -10.9kcal/mole IC50: 23.9nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cellsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 22.9nM ΔG°: -10.8kcal/mole IC50: 26.6nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential prei...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat cortexMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential prei...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 27.6nM ΔG°: -10.7kcal/mole IC50: 31.8nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 27.9nM ΔG°: -10.7kcal/mole IC50: 31.8nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potentia...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 28.3nM ΔG°: -10.7kcal/mole IC50: 32.6nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 28.5nM ΔG°: -10.7kcal/mole IC50: 33.3nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 28.6nM ΔG°: -10.7kcal/mole IC50: 33.4nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potentia...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmacology
Curated by ChEMBL
School Of Pharmacy And Pharmacology
Curated by ChEMBL
Affinity DataKi: 42.3nM ΔG°: -10.5kcal/mole IC50: 48.9nMpH: 7.4 T: 2°CAssay Description:Protocol 1: The assay was conducted following the literature reference Meyer E. M., et al., Analysis of 3-(4-Hydroxy, 2-Methoxybenzylidene) Anabasein...More data for this Ligand-Target Pair